Library / MOTS-c
Mostly lab & animal studies
MOTS-c
Mitochondria-derived peptide · Longevity
What it is
A small peptide encoded in the DNA of mitochondria, the cell's power plants. It appears to act like a hormone that helps regulate metabolism.
What research covers
Mouse studies show improved insulin sensitivity and exercise-like effects. Human data is limited to natural levels measured in blood and early-stage studies of related compounds.
Reported side effects
- Little human safety data
- Possible low blood sugar
Not suitable for, or talk to a doctor first
- Diabetes treated with insulin, without medical advice
- Pregnancy
Legal status
| Australia | Not an approved medicine in Australia. Peptides like this are generally prescription-only (Schedule 4) and need a prescription to import. Check current rules with the TGA. |
|---|---|
| United States | Not FDA-approved. |
| Sport | Athletes should check the current WADA prohibited list, which changes every year. |
Rules change. Check with the TGA (Australia), your local regulator, or WADA for sport.
Key references
- Lee et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab, 2015.
General information, not advice. Talk to a qualified healthcare professional before starting, changing or stopping anything.